For enable Proxy in User profile follow the below steps.
1. Runas cmd with admin ID.
2. open regedit.
3. Go to the below path
HKEY_USERS\S-1-5-21-2109121320-3783150902-XXXXXXXX-XXXX\Software\Policies\Microsoft\Internet Explorer\Control Panel
Change the DWORD Value to '0' for enable.
If you want to disable it change the Value to '1'
1. Runas cmd with admin ID.
2. open regedit.
3. Go to the below path
HKEY_USERS\S-1-5-21-2109121320-3783150902-XXXXXXXX-XXXX\Software\Policies\Microsoft\Internet Explorer\Control Panel
Change the DWORD Value to '0' for enable.
If you want to disable it change the Value to '1'